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However, theyre much more common in middle-aged and elderly dogs

Additional complexity arises with SIRT6, which deacetylates and stabilizes the anti-metastatic protein GILZ, preventing its ubiquitin-mediated degradation ( Figure 2 Table 1 Molecular mechanisms and oncological outcomes of SIRT modulation across diverse cancer types

Given this landscape, our review emphasizes pancreatic malignancies as representative and translationally relevant models for GLP-1R-targeted nanoplatforms