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Dysregulation of KEAP1-NRF2 activity has been observed in ALS cellular and animal models, and confirmed in human ALS tissue [67, 141, 243]

Interestingly, flavonol and phenolic acid derivatives molecules are taking the most attention as these possess several biochemical responses [12-14]

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10.1016/S0954-6111(03)00026-X 80 GronebergD

Oleanolic acid inhibits increased cellular and mitochondrial ROS production in obese diabetic db/db mice and the authors speculate that Nrf2GCLc-mediated stabilization of mitochondrial GSH pool may be involved in the protective actions of oleanolic acid [118]