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Unlike conventional cellular and mammalian models, zebrafish offer distinct advantages for real-time live imaging, rapid genetic manipulation, and conserved immune and metabolic pathwaysmaking them particularly suitable for mechanistic studies of natural products and novel compound screening (Sukardi et al., 2011)

In the phase 1b/2a study, once-weekly subcutaneous amycretin at a dose of 60 mg resulted in 24.3% weight loss at week 36, with a tolerability profile consistent with that of GLP-1 and AMYR agonists

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