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Conclusions were drawn by considering the consistency of findings across studies and giving greater weight to evidence derived from human clinical investigations whenever available

EndoC-H1 sublines were maintained in DMEM at 5 mM d-glucose supplemented with 2% BSA, 50 M -mercaptoethanol, 10 mM nicotinamide, 5.5 g ml 1 transferrin, 6.7 ng ml 1 sodium selenite, and 1% penicillin/streptomycin 40