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Endocrinology 144 , 51455148 (2003)

Tirzepatide after semaglutide failure has been shown to produce continued weight loss in patients who had stopped responding to semaglutide

Chuang Y-C

15 proposed that deprotonation of Cys497 TrxR occurs either through direct proton transfer from Cys497 TrxR to Cys35 Trx or via solvent water molecules