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Among the drug classes under investigation for AD are the glucagon-like peptide-1 receptor agonists (GLP-1RAs), which are approved for the treatment of type 2 diabetes (T2D), obesity and cardiovascular disease

However, about half of the patients who take these drugs stop within a year because of unwanted side effects

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The combined primary endpoint of death from cardiovascular disease, nonfatal myocardial infarction, or nonfatal stroke occurred in 569 (6.5%) of patients in the semaglutide group versus 701 (8.0%) of patients in the placebo group, yielding a significant hazard ratio of 0.8 for a 20% relative risk reduction

Ventricular tachycardia and AF were reported in two subjects in the placebo group, while hypotension and UTIs were reported in two subjects in the treatment group