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Clonidine: Clonidine is an alpha-2 adrenergic agonist used off-label to alleviate opioid withdrawal symptoms such as anxiety, agitation, sweating, and high blood pressure

While some may support modest weight loss through fiber or satiety mechanisms, none trigger the specific GLP-1 receptor activation that makes prescription medications effective

(World Health Organisation, 2011)

Visible changes often show before dramatic weight drops

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