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(33) analyzed the suprachiasmatic nucleus (SCN) of mice that underwent 1 week of urolithin A (20 mg/kg/day) or vehicle pre-treatment prior to dextran sulfate sodium-induced intestinal inflammation to study the effects of urolithin A on the expression of central clock genes

Evidence in humans is limited, but caution is warranted

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According to FDA's publicly available guidance, compounded drugs may be appropriate when a patient's medical need cannot be met by an FDA-approved drug or when an FDA-approved product is unavailable due to a drug shortage

Yes, timing matters