The most important NP-based drug delivery systems used as carriers for skin cancer treatment are vesicular systems such as liposomes, niosomes, transferosomes, and ethosomes (Fig
About 50% of patients with melanoma have BRAF mutations and 1520% of NRAS mutations leading to the constitutive activation of the MAPK signaling pathway [2] and Chattopadhyay et al
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Key contributors to atherogenesis include oxidative stress (excess ROS oxidizing lipids and damaging endothelial cells), vascular inflammation (cytokine and chemokine release recruiting more immune cells), endothelial dysfunction (reduced NO bioavailability and loss of barrier integrity), and dyslipidemia (elevated LDL/triglycerides and low HDL)