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van Bloemendaal, L., Ten Kulve, J

TT-OAD allosterically promotes conformational rearrangement of the central polar network to stabilize the fully active receptor conformation that allows coupling to G protein

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A clinical trial of once-weekly TZT in T2DM patients illustrated that at 26 weeks of treatment, TZT led to the significant reduction of intercellular adhesion molecule 1 (ICAM-1), growth differentiation factor 15 (GDF-15), chitosan-3 like protein 1 (YKL-40), leptin and CRP compared to the baseline values