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To determine if the increased jejunal surface area was mediated by increased proliferation, the percentage of Ki67-positive nuclei was quantified in jejunal sections

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This work therefore adds an additional layer of regulation for GLP-1/Notch activity, namely that the interaction between a Delta-like membrane-bound ligand and the Notch receptor at the surface of stem cells within an adjacent tissue is favoured by increasing levels of COL IV, and thus most likely the stiffness, of the surrounding basement membrane 34

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