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Studies indicate that most oral GSH is rapidly broken down by digestive enzymes in the upper gastrointestinal tract, resulting in low absorption of the intact molecule

Most common: mild injection site reactions (redness, bruising), temporary flushing or warmth after injection, vivid dreams during the night-dose phase, mild water retention in weeks 1-2

Other systemic illnesses, such as diabetes and hyperthyroidism, or organ diseases affecting the liver and kidneys, can also contribute to deficiency by either preventing normal absorption or disrupting vitamin storage

All of these adverse events were classified as grade 1 and resolved spontaneously without intervention

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