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We previously demonstrated that melanocytes obtained from normally pigmented vitiligo skin show cellular and molecular alterations characterized by constitutive activation of antioxidant enzymes 1 and defects in mitochondrial metabolism reflected in altered expression and activity of complex I, increased generation of reactive oxygen species (ROS), low ATP production, and modified expression of some glycolytic enzymes 2

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3.6.3 Multimodal synergistic therapeutics DDS enables urate-lowering + anti-inflammatory combinatorial strategies through co-delivery systems