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Effect of preceding drug therapy on the renal and cardiovascular outcomes of combined sodium-glucose cotransporter-2 inhibitor and glucagon-like peptide-1 receptor agonist treatment in patients with type 2 diabetes and chronic kidney disease

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Subgroup analyses showed significant difference in FPG reduction between the exenatide group (1.02 mmol/L, 1.38 to 0.67, I 2 = 0%, P = 0.49) and sitagliptin group, and a significant reduction in liraglutide group compared to sitagliptin groups (1.14 mmol/L, 1.40 to 0.88, I 2 = 0%, P = 0.56) as well

It turned out that most things other than water, protein, and some salts and sugar were performance impairers

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