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Absolute Contraindications Personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Known pancreatitis active or recurrent Pregnancy significant weight loss is contraindicated, and teratogenic risk has been identified Anyone with a history of a restrictive eating disorder CRITICAL FOR EATING DISORDER CLINICIANS: GLP-1 medications are currently contraindicated in active anorexia nervosa and other restrictive eating disorders

SELECT trial: GLP-1 RAs in non-diabetic patients The SELECT trial represented a paradigm shift by evaluating semaglutide exclusively in patients without diabetes

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Studies indicate that oncolytic viruses can be combined with immune checkpoint inhibitors to further enhance the immune systems attack on tumors (145)

No planning target volumes were added because the patient was treated with proton therapy