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Finally, if the serum cobalamin concentration at the time of reevaluation is subnormal [lower than normal], further work-up is required to definitively diagnose the underlying disease process and cobalamin supplementation should be continued weekly or bi-weekly

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demonstrated that a chitosan-based mucoadhesive microemulsion offered superior brain-targeting capabilities compared with polymeric nanoparticles due to enhanced diffusion through the nasal mucosa, resulting in higher brain concentrations and greater intranasal bioavailability, making it a promising non-invasive technique for treating brain disorders (Shah et al., 2021)