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MT-2 incorporates a D-phenylalanine substitution at position 7 and a lactam bridge between positions 4 and 10, modifications that enhance receptor binding affinity and metabolic stability relative to native alpha-MSH

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Biochem Biophys Res Commun 495:4652 Lukey MJ, Greene KS, Erickson JW, Wilson KF, Cerione RA (2016) The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

This story was originally published July 8, 2024

"The amino-acid sequence in the phenylalanyl chain of insulin