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These symptoms occur especially at the beginning of treatment or after a dose increase and improve over time in many patients

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The residual compound load is higher, and GI sensitivity tends to increase with longer tirzepatide exposure at these doses

It is a natural protective mechanism in organisms, which can reduce the damage of harmful light exposure to photoreceptors and RPE cells by synthesizing photoprotective pigments (such as melanin and lipofuscin) to absorb blue light, activate antioxidant enzymes, neutralize free radicals, etc