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Those mechanisms are why the medication works

Monitoring Strategy Baseline (before starting): Complete pain assessment with validated tools Neurological examination Basic metabolic panel, HbA1c (if diabetic), vitamin B12, TSH INR if on warfarin Cardiovascular risk assessment Ongoing: Pain assessment every 4-8 weeks initially, then every 12 weeks INR weekly 2 weeks then monthly if on warfarin Neurological examination every 6-12 months Annual laboratory monitoring for long-term use 4

Table 1 summarizes the characteristics of PGN, d-CGN, and CGN

Mullins R, Reiter D, Kapogiannis D

Ex-4 also enhances hMSC resistance to high-glucose and oxidative stress conditions by activating GLP-1AMP-activated protein kinase (AMPK) [17, 18]