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While effective for general users, it lacks the tailored focus on GLP-1-specific nutrition metrics like fiber and protein intake

Prespecified covariates were the baseline value of the outcome, diabetes duration, and sulfonylurea use

63 Building on this approach, Pathway-Level Information Extractor (PLIER) further integrates biological priors, such as pathway and marker gene sets, to improve interpretability and separate biological variation from technical noise particularly valuable for aging muscle tissue, in which subtle transcriptomic shifts are challenging to resolve

Keep it light in the beginning, but be consistent to improve the outcomes

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