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People with diabetes report a higher frequency of gastrointestinal symptoms compared with those without diabetes

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Implications for Long-Term Weight Management As such, they conclude: This evidence cautions against short-term use of weight management medications, emphasizes the need for further research into cost-effective strategies for long term weight control, and reinforces the importance of primary prevention. The study findings cast doubt on the notion that GLP-1 receptor agonists are a perfect cure for obesity, says a US researcher in a linked editorial

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Contrave's mechanism is more narrowly focused on central appetite regulation