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To overcome these difficulties, there is ongoing research into the use of in vivo imaging techniques, such as dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) and arterial spin labeling MRI (ASL MRI), which may easily detect subtle changes in BBB permeability

doi: 10.3389/fimmu.2019.01050 Received 16 July 2018 Accepted 24 April 2019 Published 09 May 2019 Volume 10 - 2019 Edited by Robert Murray Hamilton, Hospital for Sick Children, Canada Reviewed by Rui Li, University of Pennsylvania, United States

Similar dynamic motions of the receptor relative to the heterotrimeric G-protein have recently been detected by cryo-EM for other receptors

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