Second, our comorbidity ascertainment relied on recorded diagnoses within the Luxmed system, which may be incomplete and could lead to under-documentation of risk factors, potentially misclassifying some patients in the BMI 2729.9 kg/m 2 without documented comorbidities group
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Additionally, current research is focused on nanoscale delivery systems to increase the bioavailability and improve drug stability, to enhance the therapeutic efficacy of these compounds