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Several commenters noted that 12 months is not sufficient as hospitals typically pull the data several months before posting and have claims adjudication lags effectively meaning that hospitals will only be able to use 6 to 8 months of data

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

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This lack of significant improvement may be attributed to the activation of VEGF-independent angiogenic pathways, the recruitment of proangiogenic stromal cells, the induction of vasculogenesis or even the dose of the antiangiogenic agent used, which may reduce the size of blood vessel pores, further obstructing the delivery of this antibody [30, 39, 40]