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Similar to the lymphocytic thyroid infiltration observed in hypertension, histopathological examinations demonstrate lymphocytic infiltration and loss of melanocytes in lesional skin, suggesting comparable immunopathogenic pathways
Shaking can shear and destroy the peptide chains
Therefore, increased ROS/RNS levels induced by several clinical conditions may play a deleterious effect on different biomolecules (e.g., lipids, proteins and nucleic acids), organelles and antioxidant defenses, leading to exacerbate nitro-oxidative stress, mitochondrial dysfunction, glial activation and inflammatory response
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