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DSIP is found in both free and protein-bound forms in the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs including the gut secretory cells, pancreas (where it co-localises with glucagon), and plasma with brain and plasma DSIP concentrations showing a marked diurnal variation that correlates with circadian rhythm in humans, with levels lowest in the morning and higher in the afternoon

The Food and Drug Administration (FDA) recently accepted Novo Nordisks application to produce its oral version of Wegovy

That framing is helpful because it shows the identity of the stack isnt tied to one peptide alone

But it creates a problem

Eur J Endocrinol (2020) 182(5):R6782