19 Across the included studies, sample sizes ranged from 8 to 193 participants, and participants ages ranged from 18 to 93 years
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Bhide P, Pundir J, Gudi A, Shah A, Homburg R, Acharya G
Although GLP-1 receptors in the retina, ganglion cells and central nervous system play a neuroprotective role by suppressing neuroinflammationsuggesting no direct causalitythe rapid normalization of glycemic control and weight loss may disrupt pre-existing vascular stability, potentially increasing the risk of NAION, they wrote
GIP has been shown to decrease food intake while blunting the metabolic adaptive responses that usually occur with calorie restriction resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids