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PMCID: PMC7037223 Khavinson VKh, Kuznik BI, Tarnovskaia SI, Lin'kova NS

Studies on cell cultures analyzed: Effect on hTERT gene expression (catalytic subunit of telomerase) Telomerase activity in various cell lines Telomere length in cell models Pineal gland and melatonin: Due to its origin from pineal peptide, research includes: Effect on pinealocyte cells in vitro Interactions with melatonin synthesis in cell models Regulation of genes related to circadian rhythm Research on Cell Cultures The literature describes the use of epithalon in research on: Human fibroblasts Cancer cell lines Primary cell cultures In vitro models of cellular aging Limitations of Interpretation Please note that: In vitro studies do not reflect the complexity of the organism Mechanisms observed in cultures may not occur in vivo Further research is required to understand the full effect Applications in Scientific Research Telomere biology Testing the regulation of telomerase expression In vitro models of cellular aging Telomere length analysis Research on genome stability Research on the Pineal Gland Pinealocyte function Regulation of melatonin synthesis The effect of peptides on the endocrine glands Molecular Biology Gene expression studies Proteomic analyses Mechanisms of transcription regulation Chronobiology Circadian rhythm models Regulation of the biological clock Peptide-receptor interactions Reservations IMPORTANT: The product is intended for in vitro testing only

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Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release