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MTA144, utilizes a pyridoxal phosphate-dependent amino transferase, with pyruvate as an amino acceptor to catalyze the deamination of HFB1 to produce 2-keto-HFB1 (Heinl et al., 2011

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VPA is used to treat psychiatric disorders and as such there is an association with accidental or deliberate overdose, the incidence of which is increasing [135, 136]