glp-1 agonists and inflammation Can one drug do it all? Reviewing the expanding clinical universe of GLP-1_receptor_som_behandling_af_steatotisk_leversygdom - SDU

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Cao C, Ren X, Kharbanda S, Koleske A, Prasad KVS, Kufe D

In contrast, FGF23 binds to the KlothoFGFR complex and activates the Mitogen-Activated Protein Kinase/Extracellular signal-Regulated Kinase 1 and 2 pathway, leading to the suppression of CYP27B1 and upregulation of the catabolic enzyme 24-hydroxylase (CYP24A1), which accelerates the degradation of 1,25(OH)D (13)

Die topische Anwendung soll genau jene Signale wieder verstrken, die in jungen Jahren reichlich vorhanden waren ohne dabei in die Hormonregulation einzugreifen