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Exercise-Induced Oxidative Stress Intense or prolonged exercise generates substantial oxidative stress through increased oxygen consumption and metabolic rate, increased mitochondrial electron leakage producing reactive oxygen species, recruitment of inflammatory immune cells to exercising muscles, and mechanical stress on tissues producing oxidative damage

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The net effect of these forces is shrinkage of the central blood volume, which decreases renal perfusion and leads to sodium retention through activation of the renin-angiotensin system

Wong CK, McLean BA, Baggio LL, et al