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Many TCM metabolites contain PAINS-defining substructures, and most PAINS meet druglikeness criteria, making them hard to exclude with conventional filters
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It is much more common in women, especially those between the second and third decades of life (219)
Notably, oxidative stress is linked with the activation of protein kinase C (PKC), which is normally consistent with impaired insulin signaling and tissue damage in experimental models of diabetes (King and Brownlee, 1996)
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