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National Academies Press, Washington, DC

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Beyond myocardial hypertrophy, left ventricular diastolic dysfunction and myocardial fibrosis are key characteristics of HFpEF pathology 22,23,52

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Besides, immune checkpoint blockade and radiotherapy as potential options also enhance lipid-peroxidizing activity and GSH-depleting activity to trigger tumor cells death [264, 265], indicating that lipid peroxidation is a promising and effective therapeutic strategy for suppressing tumor growth