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Meet our doctors Last reviewed: 19 Jun 2026 Sources Glucagon-like peptide-1 (GLP-1): a gut hormone of potential interest in the treatment of diabetes, Bioessays [accessed 05 March 2026] Obesity Treatment (2023), NHS [accessed 05 March 2026] Semaglutide, National Institute for Health and Care Excellence [accessed 05 March 2026] Wegovy dosing schedule, Wegovy.com [accessed 05 March 2026] Wegovy (semaglutide): a new weight loss drug for chronic weight management, BMJ [accessed 05 March 2026] Weight loss injections NHS weight loss injections GLP-1 for weight loss Can doctors help with weight loss

Key Takeaway: The 28-day rule typically refers to the window of safety once a vial has been punctured, while the Beyond-Use Date (BUD) refers to the overall shelf life of the unopened product

Mechanism involves enhanced GH receptor expression and angiogenesis

The fullness signals that tirzepatide amplified return to baseline levels

Eating a small, balanced meal with adequate protein and low in fat may help reduce nausea