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Exposure of cultured human hepatocytes to alcohol increased the expression of CYP-2E1 and CYP-3A3/4 up to 6-fold, but the effect appeared to be individually variable[47]

"As part of an extension trial published a year later, participants regained an average of two-thirds of the weight they shed within 12 months of discontinuing the drug." Within 12 months of discontinuing the drug, participants regained an average of two-thirds of the weight they shed

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