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Instead of increasing blood flow to the genitals, PT-141 activates melanocortin receptors in the brain that are involved in sexual desire, arousal, and sexual response

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Guanosine and uroguanosine, which target guanosine cyclase (GC-C) receptors in the intestine and kidney, lead to elevated intracellular cGMP concentrations, and high GC-C expression in L cells is associated with regulation of GLP-1 release (Friedlander et al., 2011)