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Neves D, Salazar IL, Almeida RD, Silva RM

Triple-Hormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial

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In recent years, advances in cryo-electron microscopy (cryo-EM) have enabled structural determination of a large number of class B1 GPCRs bound to their endogenous agonists, and coupled to G s , including that of the GLP-1R, which confirm engagement of these peptides with both the ECD and the TMD 10,11,12,13,14,15,16,17,18,19,20,21

GLP-1 receptor agonists act by stimulating insulin secretion, suppressing glucagon secretion, delaying gastric emptying, decreasing appetite, and decreasing body weight and have been shown to be effective in the treatment of T2D