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Sikiric, et al, demonstrated its possible use to heal distended stomachs and noted that it has been used safely and with some effect in trials for irritable bowel disease
The copper peptide research overview covers the full mechanism and the ~4,000 human genes documented as GHK-Cu-responsive in Broad Institute Connectivity Map analysis
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Its action through the gut-brain axis also suggests that its gut health benefits may indirectly support neurological function
The FDA's 2023 briefing to the Pharmacy Compounding Advisory Committee cited the lack of sufficient clinical evidence for therapeutic compounding approval
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