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In the vasculature, caffeine promotes vasodilation through its ability to antagonize adenosine and stimulate endothelial cells to release nitric oxide

Additionally, patients with constipation-predominant IBS (IBS-C) exhibit significantly lower serum GLP-1 levels, which negatively correlate with abdominal pain scores

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GLP-1 and weight loss approaches are based on a plausible and documented mechanism: reduced appetite, increased satiety, slowed gastric emptying, and improved glycemic control