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755 Mechanistically, SSAT1 overexpression increases ALOX15 expression and decreases the expression levels of GPX4 and SLC7A11 in primary cortical neurons, suggesting that SSAT1/ALOX15 axis activation may aggravate brain I/R injury by triggering ferroptosis in neurons

All the products of biodegradation have been shown to be non-toxic, non-immunogenic, and non-carcinogenic, which is important for the biocompatibility of CNS drug delivery[92]

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& Chuen Li, S

CONCLUSION The t 1/2eff is considered a more clinically relevant pharmacokinetic parameter for extended-release drug formulations than for immediate-release formulations of the same active substance