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Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer

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Their randomized, double-blind, placebo-controlled trial involved 75 resistance-trained males divided into three groups: placebo , L-citrulline malate , or L-citrulline (2g) + glutathione (200mg)