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Naltrexone is typically used to treat alcohol and opioid dependence, but in this case, it works a little differently

Symptoms are often most pronounced during the initial dose titration phase and may improve as the body adjusts to treatment

doi:10.1371/journal.pone.0074420 242

Of note, one of the key protective mechanisms of GLP-1RA medications against cancer is lipolysis, which helps reduce tumorigenic adipokines such as leptin and promotes tumor-suppressive factors such as adiponectin