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Priority was given to randomized controlled trials (RCTs), cohort studies, case-control studies, and systematic reviews

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Usually, government's categorizes medicines that can be addictive as controlled substances

Metoclopramide may be considered but should only be used for a maximum of 5 days due to MHRA restrictions on prolonged use Proton pump inhibitors if acid reflux contributes to nausea Treatment breaks in severe cases, though this should only be done under medical supervision Patients should maintain regular contact with their prescribing clinician, particularly during the first three months of treatment