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Venous blood samples were drawn at times 0 (before initiation of OGTT), 30, 60, 90, 120 minutes from the indwelling catheter for measurement of glucose and insulin

We are grateful to Dr Slava Ziegler for discussions of biological experiments

Gamma aminobutyric acid agonists such as gabapentin and pregabalin can be used as second-line treatments for itching