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Furthermore, heme can drive TNF-- and ROS-mediated necroptosis [225], heme oxygenase 1-dependent ferroptosis [226], and NLRP3 inflammasome-associated pyroptosis [227], which are highly proinflammatory RCDs

It is worth noting that unlicensed medicines can be lawfully supplied in limited circumstances for example, as 'specials' manufactured to meet the specific clinical needs of an individual patient under a prescriber's direction

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Kubiszeski EH, de Medeiros SF, da Silva Seidel JA, Barbosa JS, Galera MF, Galera BB (2015) Glutathione S-transferase M1 and T1 gene polymorphisms in Brazilian women with endometriosis

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