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For tissue extracts obtained from experiments on Langendorff hearts, the peak shapes and separation were affected by interfering contaminants, so to overcome this we modified the HPLC gradient as described in the Supplementary Table 4, keeping the rest of the parameters unchanged
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The cystine/glutamate antiporter system (xCT), a disulfide-linked heterodimer composed of SLC7A11 and SLC3A2, serves as the pathway for cystine uptake into cells, where it is reduced to cysteine for the synthesis of intracellular GSH
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