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Oxidative stress, induced by ROS, triggered the translocation of Fas into lipid rafts, the formation of a Fas-associated signaling complex, and the subsequent activation of caspases-8 and -3

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Preincubation of heart mitochondria of GSH-treated old animals with inhibitor CsA (10 5 mol/L) almost completely prevented Ca 2+ -induced mitochondrial swelling, which indicates the association of this process with mPTP opening (Figure 2A)