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Disruption of this process, as seen in Astrocyte-Specific Mitochondrial Transcription Factor A Knockout (TfamAKO), causes lipid droplet (LD) accumulation, particularly in the hippocampus and cortex, along with reactive astrogliosis

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The Mesolimbic System: Lowering the Reward Volume If the hypothalamus regulates the homeostatic stomach hunger that tells you your body needs fuel, you can think of the mesolimbic system as driving your hedonic brain hunger. The mesolimbic system includes the ventral tegmental area (VTA) and nucleus accumbens (NAc)

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