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The study, published in the American Journal of Clinical Nutrition and led by investigators from Penn's Center for Weight and Eating Disorders and Penn Metabolic Medicine, is among the first to examine the long-term effects of semaglutide on eating behavior beyond the initial months of treatment

It analyzes pathway-level variants in FTO, GLP1R, MC4R, and TCF7L2 that may shape baseline GLP-1 and energy-balance biology upstream context that can support a more informed conversation with a qualified healthcare provider

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These changes often emerge even before maximum weight loss is achieved, suggesting direct pharmacologic effects beyond weight reduction alone

2025 Mar 6;135(9):e188314