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A study by the University of Michigan found that retinoic acid boosts collagen in the skin, promoting a more youthful look

AGE/RAGE action on vascular smooth muscle cells (VSMC) induces autophagy through the ERK/Akt pathway 454 and increases ROS and NOS levels through activation of NOX and NF-B, 455,456 increases oxidative stress, and accelerates atherosclerotic plaque progression

Reduced Glutathione (GSH) is the active form that carries out antioxidant functions

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Therefore, 20 articles were included in the study after passing the eligibility criteria and quality assessment (Figure 3)